Synthetic Dosage Lethality of Chromosomal Instability in yeast

This study explores chromosomal instability (CIN) in cancer using Saccharomyces cerevisiae as a model organism. By overexpressing genes to induce synthetic dosage lethality in mutated CIN genes, we aim to identify potential cancer therapy targets. Techniques include plasmid-based overexpression, homologous recombination, and various assays, with findings analyzed via ANOVA.




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