Synthetic Dosage Lethality of Chromosomal Instability in yeast
Posted on Wednesday, April 9th, 2025
This study explores chromosomal instability (CIN) in cancer using Saccharomyces cerevisiae as a model organism. By overexpressing genes to induce synthetic dosage lethality in mutated CIN genes, we aim to identify potential cancer therapy targets. Techniques include plasmid-based overexpression, homologous recombination, and various assays, with findings analyzed via ANOVA.